exRNAdisease

Entry Detail

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General Information

Database ID: exR0266652 RNA Name: hsa-miR-1286 RNA Type: miRNA Chromosome: chr22 Starnd: - Coordinate: Start Site(bp): 20249145 End Site(bp): 20249165 External Links: hsa-miR-1286

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRIO chr5 14143342 14532128 + TXLNA chr1 32179675 32198285 + CSNK1E chr22 38290691 38318084 - NT5DC2 chr3 52524385 52535054 - ERLIN1 chr10 100150094 100186033 - BTG2 chr1 203305491 203309602 + GOLGA3 chr12 132768914 132829078 - ABCA2 chr9 137007234 137028922 - SSR2 chr1 156009048 156020951 - LUZP1 chr1 23084023 23177808 - RUBCN chr3 197668867 197749727 - CBX6 chr22 38861422 38872249 - KMT2A chr11 118436490 118526832 + LAMTOR1 chr11 72085895 72103297 - PHF12 chr17 28905250 28951771 - NPTX1 chr17 80466834 80477843 - ZXDB chrX 57591652 57597545 + PHLDA3 chr1 201464278 201469237 - NIPSNAP1 chr22 29554808 29581327 - IGDCC3 chr15 65327127 65378002 - TNRC6B chr22 40044817 40335808 + DNAJC30 chr7 73680918 73683453 - ALG10B chr12 38316762 38329721 + RBM4 chr11 66638617 66668374 + ABHD14B chr3 51968510 51983409 - ATXN2L chr16 28823035 28837237 + CPA4 chr7 130293134 130324180 + FGFR1 chr8 38400215 38468834 - HDGF chr1 156742109 156766925 - ATP8B2 chr1 154325553 154351304 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001588 chr6 26204839 26205043 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC016876.2 chr17 7581964 7584086 - AC124068.2 chr15 89335053 89336161 + DNAAF4-CCPG1 chr15 55355248 55498360 - MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.