exRNAdisease

Entry Detail

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General Information

Database ID: exR0266700 RNA Name: hsa-miR-135a-5p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 97563834 End Site(bp): 97563856 External Links: hsa-miR-135a-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARPP19 chr15 52547045 52569883 - MTDH chr8 97644184 97730260 + NECTIN1 chr11 119623408 119729200 - PHTF2 chr7 77798792 77957503 + PRRC2B chr9 131373636 131500197 + SNX16 chr8 81799581 81842866 - STK38 chr6 36493892 36547479 - STK4 chr20 44966479 45080021 + TMEM181 chr6 158536436 158635428 + TOB2 chr22 41433494 41446801 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0000471 chr13 33091993 33101669 - hsa_circ_0000527 chr14 24610097 24616430 - hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + AC009032.1 chr16 69632141 69632571 + AL137127.1 chr1 19072110 19075511 - DANCR chr4 52712404 52720351 + GAS5 chr1 173858559 173868882 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SPINT1-AS1 chr15 40835808 40844387 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.