exRNAdisease

Entry Detail

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General Information

Database ID: exR0266715 RNA Name: hsa-miR-142-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 58331245 End Site(bp): 58331267 External Links: hsa-miR-142-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BLOC1S6 chr15 45587214 45615945 + BOD1 chr5 173607145 173616659 - CUL5 chr11 108008898 108107761 + ETFRF1 chr12 25195216 25209645 + SEMA7A chr15 74409289 74433958 - TNRC6B chr22 40044817 40335808 + ZNF676 chr19 22179089 22215801 - AL139011.2 chr1 160216800 160285130 - B2M chr15 44711487 44718877 + CCDC126 chr7 23597382 23644708 + EEF1A1 chr6 73515750 73523797 - MAST2 chr1 45786987 46036122 + MBD3 chr19 1573596 1592865 - MRPL18 chr6 159789812 159798436 + NDUFA2 chr5 140638740 140647785 - PEX19 chr1 160276812 160286348 - PRDX1 chr1 45511036 45523047 - RPL27 chr17 42998273 43002959 + SLC35F5 chr2 113705011 113756693 - SPDL1 chr5 169583636 169604778 + TMSB4X chrX 12975110 12977227 + VPS53 chr17 508668 721717 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000120 chr1 117944807 118009049 + hsa_circ_0001387 chr4 1902352 1936989 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC011815.1 chr18 35280867 35290201 - AC126365.1 chr17 20788071 20789584 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + AC138761.1 chr17 22266395 22288301 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.