exRNAdisease

Entry Detail

---



General Information

Database ID: exR0266827 RNA Name: hsa-miR-199a-5p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 172144592 End Site(bp): 172144614 External Links: hsa-miR-199a-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ALDH3B2 chr11 67662160 67681224 - CHD2 chr15 92900189 93027996 + COL4A2 chr13 110305812 110513209 + COX6A1 chr12 120438090 120440737 + FAM222B chr17 28755978 28855232 - FOSL2 chr2 28392448 28417317 + HIF1AN chr10 100529072 100559998 + HMGCS1 chr5 43287470 43313512 - IPO7 chr11 9384652 9448127 + KRT80 chr12 52168996 52192014 - MYRF chr11 61752642 61788518 + NFE2L1 chr17 48048329 48061545 + PLPP6 chr9 4662294 4665258 + SLC6A6 chr3 14402576 14489349 + SLC7A5 chr16 87830023 87869507 - WNT5A chr3 55465715 55490539 - XPO6 chr16 28097979 28211920 - ZMIZ1 chr10 79068966 79316528 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0000892 chr19 11941431 12014514 + hsa_circ_0000931 chr19 38226804 38231095 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004951.4 chr7 43951910 44019151 - AC095055.1 chr4 151139991 151141103 + BX284668.2 chr1 16870945 16883659 + LINC01783 chr1 16533886 16536172 - POLR2J4 chr7 43940895 44019175 - SNHG12 chr1 28578538 28583132 - TMPO-AS1 chr12 98512973 98516422 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.