exRNAdisease

Entry Detail

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General Information

Database ID: exR0266853 RNA Name: hsa-miR-206 RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 52144401 End Site(bp): 52144422 External Links: hsa-miR-206

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CAPNS1 chr19 36139953 36150353 + NPEPPS chr17 47522942 47623276 + SPRED1 chr15 38252836 38357249 + SLC30A7 chr1 100896076 100981757 + DDX5 chr17 64498254 64508199 - TRIM2 chr4 153152342 153339317 + DLG3 chrX 70444835 70505490 + LASP1 chr17 38869859 38921770 + RTL8B chrX 135020513 135022542 - FOXP1 chr3 70952817 71583993 - SDCBP chr8 58552924 58582859 + NME1-NME2 chr17 51153590 51171744 + NR2C2 chr3 14947584 15053600 + TNRC6B chr22 40044817 40335808 + CREB3L2 chr7 137874979 138002086 - NETO2 chr16 47077703 47143945 - ZNF518A chr10 96129715 96205288 + PGM2 chr4 37826660 37862937 + PRR12 chr19 49591182 49626439 + PTBP1 chr19 797075 812327 + CALM1 chr14 90396502 90408268 + NME2 chr17 51165435 51171747 + AP1S1 chr7 101154456 101161596 + MAPK1 chr22 21754500 21867680 - GID4 chr17 18039408 18068405 + SMCO4 chr11 93478472 93543391 - SS18 chr18 26016253 26091217 - CWC15 chr11 94962620 94973586 - WIPF2 chr17 40219304 40284136 + WDR5 chr9 134135365 134159968 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000816 chr17 80521229 80526077 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005332.7 chr17 68188547 68189165 + AC145207.5 chr17 81878425 81881106 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + MIR4435-2HG chr2 111006015 111523376 - NEAT1 chr11 65422774 65445540 + RMRP chr9 35657751 35658018 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.