exRNAdisease

Entry Detail

---



General Information

Database ID: exR0266941 RNA Name: hsa-miR-28-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 188688794 End Site(bp): 188688815 External Links: hsa-miR-28-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RTL8A chrX 135050932 135052196 - LYPD3 chr19 43460787 43465608 - RGMA chr15 93035273 93089204 - GLYR1 chr16 4803203 4847288 - E2F6 chr2 11444375 11466177 - PTPN23 chr3 47381011 47413435 + KCTD5 chr16 2682523 2709030 + GPCPD1 chr20 5544439 5611006 - ENSA chr1 150600851 150629612 - AMOTL2 chr3 134355874 134375479 - SSR2 chr1 156009048 156020951 - FAM102A chr9 127940582 127980989 - N4BP1 chr16 48538726 48620148 - CPSF2 chr14 92121969 92172145 + EZH1 chr17 42700275 42745049 - KIAA1522 chr1 32741830 32774970 + LONRF2 chr2 100271875 100322501 - MAPK1 chr22 21754500 21867680 - LASP1 chr17 38869859 38921770 + SMYD1 chr2 88067825 88113384 + NAPA chr19 47487637 47515091 - URGCP chr7 43875894 43926411 - SMG5 chr1 156249224 156282825 - DYRK1A chr21 37365573 37526358 + RTL8B chrX 135020513 135022542 - SLC31A1 chr9 113221544 113264492 + SEH1L chr18 12947133 12987536 + ZBTB7B chr1 155002630 155018522 + TUB chr11 8019244 8106112 + TEX261 chr2 70985942 70994873 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000417 chr12 69644908 69656342 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009065.4 chr16 2119207 2120248 + AC016876.2 chr17 7581964 7584086 - AC026362.1 chr12 122975320 122982907 + AC118758.3 chr7 56809214 56848800 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.