exRNAdisease

Entry Detail

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General Information

Database ID: exR0266944 RNA Name: hsa-miR-296-3p RNA Type: miRNA Chromosome: chr20 Starnd: - Coordinate: Start Site(bp): 58817626 End Site(bp): 58817647 External Links: hsa-miR-296-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATXN7 chr3 63864557 64003462 + BAZ2A chr12 56595596 56636816 - COL6A1 chr21 45981769 46005050 + CYLD chr16 50742050 50801935 + FAM210A chr18 13663347 13726663 - HMGCS1 chr5 43287470 43313512 - HOXC10 chr12 53985065 53990279 + HP1BP3 chr1 20740266 20787323 - KAT6A chr8 41929479 42051994 - KMT2D chr12 49018975 49059774 - KPNA6 chr1 32108056 32176563 + LASP1 chr17 38869859 38921770 + MINK1 chr17 4833340 4898061 + NFAT5 chr16 69565094 69704666 + PFN2 chr3 149964904 150050788 - RTKN chr2 74425835 74442422 - SERF2 chr15 43777087 43802589 + SLC2A4RG chr20 63739776 63744050 + STK35 chr20 2101827 2177038 + TMEM97 chr17 28319200 28328685 + TP53 chr17 7661779 7687550 - TULP3 chr12 2877223 2941138 + UBA2 chr19 34428352 34471251 + VANGL1 chr1 115641970 115698224 + ZFP91 chr11 58579063 58621550 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001867 chr9 86294689 86297981 - hsa_circ_0001866 chr9 86293355 86297981 - hsa_circ_0001046 chr2 97024782 97033111 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AC016831.1 chr7 130876809 130913310 - AC023509.1 chr12 53441741 53467528 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - PCBP2-OT1 chr12 53464468 53465057 + SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.