exRNAdisease

Entry Detail

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General Information

Database ID: exR0266947 RNA Name: hsa-miR-299-3p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 101023832 End Site(bp): 101023853 External Links: hsa-miR-299-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AFF4 chr5 132875395 132963634 - AK2 chr1 33007940 33080996 - AP3M1 chr10 74120255 74151063 - ARCN1 chr11 118572390 118603033 + CASP2 chr7 143288215 143307696 + CMIP chr16 81445170 81711762 + COL4A2 chr13 110305812 110513209 + CORO2B chr15 68578993 68727806 + DHX33 chr17 5440917 5468982 - DNAJC9 chr10 73183362 73247255 - E2F6 chr2 11444375 11466177 - FHL2 chr2 105357712 105438513 - GLCCI1 chr7 7968796 8094272 + LY6E chr8 143017982 143023832 + MAP3K14 chr17 45263119 45317029 - MAP3K2 chr2 127298730 127388465 - MAP3K20 chr2 173075435 173268015 + MBNL1 chr3 152243828 152465780 + MPZL1 chr1 167721192 167791919 + PCGF3 chr4 705748 770640 + PGK1 chrX 77910739 78129295 + PTPRJ chr11 47980558 48170841 + RAB8A chr19 16111889 16134234 + SAMD4B chr19 39342396 39385710 + SORBS3 chr8 22544986 22575788 + TCF3 chr19 1609290 1652615 - TMEM127 chr2 96248516 96265994 - USP37 chr2 218450251 218568351 - ZIC1 chr3 147393422 147510293 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0001146 chr20 34241449 34246936 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC135048.1 chr16 30948386 30956511 + DSCAM-AS1 chr21 40383083 40385358 + KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.