exRNAdisease

Entry Detail

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General Information

Database ID: exR0266961 RNA Name: hsa-miR-302a-3p RNA Type: miRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 112648186 End Site(bp): 112648208 External Links: hsa-miR-302a-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZBTB5 chr9 37438102 37465450 - PPP1R8 chr1 27830782 27851676 + ATP6V1C1 chr8 103021063 103073051 + SEC23B chr20 18507520 18561415 + FABP5 chr8 81280536 81284777 + THRAP3 chr1 36224432 36305357 + LONP2 chr16 48244300 48363122 + KLC1 chr14 103561896 103714249 + FAM222B chr17 28755978 28855232 - WASF3 chr13 26557683 26688948 + TOP2A chr17 40388525 40417896 - APP chr21 25880550 26171128 - ARL4A chr7 12686856 12690958 + PDRG1 chr20 31944337 31952046 - SCAMP2 chr15 74843730 74873365 - RAB31 chr18 9708275 9862551 + IKZF4 chr12 56007659 56038435 + RACGAP1 chr12 49976923 50033136 - MGLL chr3 127689062 128052190 - HABP4 chr9 96450169 96491336 + USP6NL chr10 11453946 11611754 - RGMA chr15 93035273 93089204 - JARID2 chr6 15246069 15522042 + BAZ1B chr7 73440406 73522293 - CLIP4 chr2 29097705 29189643 + IPO7 chr11 9384652 9448127 + SEC23IP chr10 119892730 119944657 + VLDLR chr9 2621787 2660056 + IZUMO2 chr19 50152548 50163195 - SSR1 chr6 7268306 7347446 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.