exRNAdisease

Entry Detail

---



General Information

Database ID: exR0266963 RNA Name: hsa-miR-302b-3p RNA Type: miRNA Chromosome: chr4 Starnd: - Coordinate: Start Site(bp): 112648489 End Site(bp): 112648511 External Links: hsa-miR-302b-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand RPP14 chr3 58306247 58324695 + SWSAP1 chr19 11374666 11376951 + GPBP1 chr5 57173948 57264679 + C18orf21 chr18 35972625 35979286 + PXYLP1 chr3 141228726 141367753 + ALG5 chr13 36949738 37000261 - SERINC1 chr6 122443351 122471807 - RGMA chr15 93035273 93089204 - CLCN6 chr1 11806096 11848079 + KCTD10 chr12 109448655 109477359 - PLS3 chrX 115561174 115650861 + RPLP1 chr15 69452814 69456205 + DNAJB6 chr7 157335381 157417439 + SYAP1 chrX 16719612 16765340 + RNF149 chr2 101271219 101308701 - SLC35G1 chr10 93893973 93956062 + MSL1 chr17 40121971 40136917 + SND1 chr7 127652194 128092609 + WASF3 chr13 26557683 26688948 + CTR9 chr11 10751246 10801625 + HMGCS1 chr5 43287470 43313512 - CDK6 chr7 92604921 92836594 - WDR37 chr10 1049538 1132384 + ATP6V1B2 chr8 20197381 20226819 + CTSC chr11 88293592 88337761 - HSPA9 chr5 138553756 138575416 - ZNF281 chr1 200404940 200410056 - CELF2 chr10 10798397 11336675 + TNRC6A chr16 24610209 24827632 + ATP13A2 chr1 16985958 17011928 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011503.2 chr19 23927788 23929287 + AC021078.1 chr5 149494314 149504670 - AC125257.1 chr17 41848518 41851447 - AL049840.4 chr14 103694516 103695050 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - MIR17HG chr13 91347820 91354579 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.