exRNAdisease

Entry Detail

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General Information

Database ID: exR0266993 RNA Name: hsa-miR-31-5p RNA Type: miRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 21512158 End Site(bp): 21512178 External Links: hsa-miR-31-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ABHD4 chr14 22598237 22613215 + ANKRD52 chr12 56237807 56258384 - BACH2 chr6 89926528 90296908 - CHD1 chr5 98853985 98928957 - CTNND1 chr11 57753243 57819546 + FAM222B chr17 28755978 28855232 - FURIN chr15 90868588 90883458 + GRK2 chr11 67266473 67286556 + HACD3 chr15 65530418 65578349 + HOXA7 chr7 27153716 27157936 - KIF3B chr20 32277651 32335011 + LONRF1 chr8 12721906 12756073 - MAP3K14 chr17 45263119 45317029 - PATL1 chr11 59636716 59669037 - PLCB1 chr20 8077251 8968360 + PPP1R3C chr10 91628442 91633071 - PRRC2B chr9 131373636 131500197 + RTL8B chrX 135020513 135022542 - RTL8C chrX 135032355 135033546 + SERF2 chr15 43777087 43802589 + SMAD3 chr15 67063763 67195169 + TRIM35 chr8 27284886 27311272 - XPNPEP3 chr22 40857077 40932815 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001728 chr7 99695763 99695845 - hsa_circ_0001349 chr3 152132729 152150709 + hsa_circ_0000241 chr10 70847874 70856944 + hsa_circ_0000931 chr19 38226804 38231095 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004832.5 chr22 30420512 30420912 + AC016876.2 chr17 7581964 7584086 - AC074117.1 chr2 27356246 27367622 + AC087477.2 chr15 96354237 96405235 + GAS5 chr1 173858559 173868882 - MAGI2-AS3 chr7 79452877 79471208 + MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.