exRNAdisease

Entry Detail

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General Information

Database ID: exR0267132 RNA Name: hsa-miR-338-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 81125887 End Site(bp): 81125908 External Links: hsa-miR-338-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCY9 chr16 3953387 4116442 - ARPC1B chr7 99374249 99394816 + CALU chr7 128739292 128773400 + CDT1 chr16 88803789 88809258 + ENSA chr1 150600851 150629612 - ERG28 chr14 75649791 75660876 - GTSE1 chr22 46296870 46330810 + KDSR chr18 63327726 63367228 - NONO chrX 71283192 71301168 + PALLD chr4 168497052 168928457 + PURB chr7 44876299 44885530 - RAB14 chr9 121178133 121223014 - TANC2 chr17 63009556 63427699 + TRIM33 chr1 114392790 114511203 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001025 chr2 69565029 69565697 - hsa_circ_0000284 chr11 33307958 33309057 + hsa_circ_0001085 chr2 191765289 191789319 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC008738.7 chr19 33207129 33207639 + AC109460.3 chr16 28974804 28990775 + KCNQ1OT1 chr11 2608328 2699994 - LINC00943 chr12 126723412 126749027 + MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SDCBP2-AS1 chr20 1325405 1378735 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.