exRNAdisease

Entry Detail

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General Information

Database ID: exR0267142 RNA Name: hsa-miR-342-3p RNA Type: miRNA Chromosome: chr14 Starnd: + Coordinate: Start Site(bp): 100109715 End Site(bp): 100109737 External Links: hsa-miR-342-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.6 chr16 29812261 29820092 + ACVR1B chr12 51951699 51997078 + CRIM1 chr2 36355778 36551135 + E2F1 chr20 33675477 33686385 - EXOSC6 chr16 70246778 70251940 - IGFBP4 chr17 40443450 40457725 + LASP1 chr17 38869859 38921770 + PAGR1 chr16 29816152 29822489 + UBTF chr17 44205033 44221626 - USP31 chr16 23061406 23149270 - WDR77 chr1 111439890 111449256 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC010327.5 chr19 55216660 55221616 + AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AL356488.2 chr1 109100193 109100619 + CKMT2-AS1 chr5 81201341 81301565 - H19 chr11 1995176 2001470 - LINC00894 chrX 149938613 150224580 + NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG20 chr17 77086716 77099902 + SNHG7 chr9 136721366 136728184 - STAG3L5P-PVRIG2P-PILRB chr7 100336104 100367831 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.