exRNAdisease

Entry Detail

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General Information

Database ID: exR0267148 RNA Name: hsa-miR-34a-5p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 9151735 End Site(bp): 9151756 External Links: hsa-miR-34a-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TMEM109 chr11 60914158 60923443 + RTL8A chrX 135050932 135052196 - CD151 chr11 832887 839831 + PXDC1 chr6 3722614 3752026 - PTGFRN chr1 116909916 116990353 + STK38L chr12 27243968 27325959 + CPSF6 chr12 69239569 69274358 + TNRC6B chr22 40044817 40335808 + MTMR9 chr8 11284816 11328146 + NDST1 chr5 150485818 150558211 + SEC61A1 chr3 128051641 128071683 + KMT2D chr12 49018975 49059774 - HMGCS1 chr5 43287470 43313512 - ARPP19 chr15 52547045 52569883 - CALM3 chr19 46601074 46610782 + MYCN chr2 15940550 15947007 + ZNF623 chr8 143636013 143656418 + PHF19 chr9 120855651 120894896 - NFKBIA chr14 35401511 35404749 - TKFC chr11 61333210 61353295 + NCOA1 chr2 24491914 24770702 + ZDHHC17 chr12 76763588 76853696 + PPARD chr6 35342558 35428191 + TOB2 chr22 41433494 41446801 - ATXN2L chr16 28823035 28837237 + AGTRAP chr1 11736084 11754802 + SMC1A chrX 53374149 53422728 - JAG1 chr20 10637684 10673999 - ACSL1 chr4 184755595 184826818 - IL2RB chr22 37125843 37175054 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001723 chr7 91924202 91948826 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0001865 chr9 86292641 86293514 - hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC018521.1 chr17 47945424 47981736 + AC116913.1 chr15 66488658 66492109 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC00665 chr19 36313067 36331770 - NEAT1 chr11 65422774 65445540 + SNHG7 chr9 136721366 136728184 - TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.