exRNAdisease

Entry Detail

---



General Information

Database ID: exR0267189 RNA Name: hsa-miR-3648 RNA Type: miRNA Chromosome: chr21 Starnd: + Coordinate: Start Site(bp): 8987026 End Site(bp): 8987046 External Links: hsa-miR-3648

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand MT-CO2 chrMT 7586 8269 + THAP7 chr22 20999104 21002196 - CERS4 chr19 8206736 8262421 + ARL8B chr3 5122245 5180912 + EEF1G chr11 62559596 62574086 - FNBP4 chr11 47716494 47767443 - PTGES3 chr12 56663341 56688408 - AP002990.1 chr11 62559603 62591531 - PTCH2 chr1 44819844 44843253 - MAPK9 chr5 180233143 180292099 - ACTG1 chr17 81509971 81523847 - ECPAS chr9 111360692 111484745 - RNF126 chr19 647526 663233 - SF3A2 chr19 2236824 2248655 + TPT1 chr13 45333471 45341370 - AKIRIN2 chr6 87674860 87702233 - LZTS3 chr20 3162617 3173592 - AL133352.1 chr10 100505628 100529881 - ATP6V0A2 chr12 123712353 123761755 + SET chr9 128683424 128696400 + SH3GLB2 chr9 129007036 129028303 - PAM16 chr16 4331549 4355607 - LRRC45 chr17 82023305 82031151 + SRRM2 chr16 2752626 2772538 + NDUFB8 chr10 100523740 100530000 - GAPDH chr12 6534512 6538374 + CORO7-PAM16 chr16 4340251 4420494 - SKI chr1 2228319 2310213 + SSR2 chr1 156009048 156020951 - ARRDC4 chr15 97960703 97973833 + miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.