exRNAdisease

Entry Detail

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General Information

Database ID: exR0267352 RNA Name: hsa-miR-422a RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 63870989 End Site(bp): 63871010 External Links: hsa-miR-422a

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARHGAP11A chr15 32615144 32639941 + CPEB3 chr10 92046692 92291078 - FOSL1 chr11 65892049 65900573 - ISCA1 chr9 86264546 86283102 - KDM5A chr12 280057 389320 - MAP3K14 chr17 45263119 45317029 - ORAI1 chr12 121626550 121642677 + PIK3R3 chr1 46040140 46133036 - PLEKHO2 chr15 64841883 64868002 + SEH1L chr18 12947133 12987536 + SOX4 chr6 21593751 21598619 + TMEM245 chr9 109015135 109119947 - TOB2 chr22 41433494 41446801 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001459 chr4 178274461 178274882 + hsa_circ_0001460 chr4 178274461 178281831 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AL049795.2 chr1 32170733 32176568 + KCNQ1OT1 chr11 2608328 2699994 - LINC00641 chr14 21200079 21206900 - MALAT1 chr11 65497688 65506516 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.