Entry Detail



General Information

Database ID:exR0267369
RNA Name:hsa-miR-4262
RNA Type:miRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):11836943End Site(bp):11836959
External Links:hsa-miR-4262



Disease Information

Disease Name:Cystic Fibrosis
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D003550
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas



Expression Detail

GEO ID:GSE135119
Description:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Experimental Design:Disease vs Control
Case Disease Type:Cystic Fibrosis
Case Disease SubType:NA
Case Sample:Cystic Fibrosis
Control Sample:Healthy
Number of Case:5
Number of Control:5
Number of Samples:10





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001550
chr5
167915606
167921655
+
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001522
chr5
122881110
122893258
+
hsa_circ_0000892
chr19
11941431
12014514
+
hsa_circ_0001361
chr3
171830241
171851336
+
hsa_circ_0000931
chr19
38226804
38231095
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC010442.1
chr5
466124
473098
-
AC010655.4
chr7
128455840
128493859
+
AC021078.1
chr5
149494314
149504670
-
AC144548.1
chr12
110387463
110445548
-
AL035458.2
chr20
34234840
34281173
-
AL049543.1
chr6
28587378
28591747
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00667
chr18
5237826
5290608
+
MALAT1
chr11
65497688
65506516
+
MIR4458HG
chr5
8450701
8486930
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
SNHG1
chr11
62851984
62855953
-
SNHG5
chr6
85650491
85678932
-
SNHG7
chr9
136721366
136728184
-
THUMPD3-AS1
chr3
9349689
9398579
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE135119
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19117
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2346
Sample treatment protocol:NA
RNA Extract protocol:Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit.
RNA library preparation protocol:Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.



Reference

PMID:31664087
Title:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Author:Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H
Journal:Sci Rep. 2019 Oct 29;9(1):15483.
Description:we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.