exRNAdisease

Entry Detail

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General Information

Database ID: exR0267441 RNA Name: hsa-miR-4426 RNA Type: miRNA Chromosome: chr1 Starnd: + Coordinate: Start Site(bp): 192716333 End Site(bp): 192716349 External Links: hsa-miR-4426

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand UFC1 chr1 161152776 161158856 + NDUFA4 chr7 10931943 10940153 - N4BP3 chr5 178113532 178126081 + MTRNR2L11 chr1 237943724 237945275 - RNF181 chr2 85595725 85597708 + VMP1 chr17 59707192 59842255 + DDB1 chr11 61299451 61342596 - SAP18 chr13 21140514 21149084 + DOCK6 chr19 11199295 11262524 - NSMAF chr8 58583508 58659853 - APP chr21 25880550 26171128 - TMEM170A chr16 75443054 75465497 - TKFC chr11 61333210 61353295 + CTSZ chr20 58995185 59007254 - AL136454.1 chr1 192716132 192716653 + TPT1 chr13 45333471 45341370 - PTPN6 chr12 6946468 6961316 + CAPNS1 chr19 36139953 36150353 + CCNL2 chr1 1385711 1399335 - RABGAP1L chr1 174159410 174995308 + RACK1 chr5 181236897 181248096 - HMGN2 chr1 26472440 26476642 + SEZ6L2 chr16 29871159 29899547 - GAPDH chr12 6534512 6538374 + CD52 chr1 26317958 26320523 + PCBP2 chr12 53452102 53481162 + NDUFA11 chr19 5891276 5904006 - REXO1 chr19 1815248 1848483 - ZNF655 chr7 99558406 99576453 + DCAF12 chr9 34086387 34127399 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC023509.1 chr12 53441741 53467528 + AC105942.1 chr1 94927361 94963616 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.