Entry Detail



General Information

Database ID:exR0267542
RNA Name:hsa-miR-4524b-5p
RNA Type:miRNA
Chromosome:chr17
Starnd:+
Coordinate:
Start Site(bp):69099570End Site(bp):69099590
External Links:hsa-miR-4524b-5p



Disease Information

Disease Name:Cystic Fibrosis
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D003550
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas



Expression Detail

GEO ID:GSE135119
Description:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Experimental Design:Disease vs Control
Case Disease Type:Cystic Fibrosis
Case Disease SubType:NA
Case Sample:Cystic Fibrosis
Control Sample:Healthy
Number of Case:5
Number of Control:5
Number of Samples:10





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001731
chr7
100731990
100738448
+
hsa_circ_0001723
chr7
91924202
91948826
+
hsa_circ_0001159
chr20
40161688
40179999
-
hsa_circ_0001699
chr7
40027197
40041630
+
hsa_circ_0000826
chr18
9182379
9221997
+
hsa_circ_0001263
chr3
5215701
5216099
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC004069.1
chr4
105137280
105140619
-
AC009022.1
chr16
69976297
70065948
-
AC021078.1
chr5
149494314
149504670
-
AC079781.5
chr7
97851688
97972985
-
AC114980.1
chr5
93860669
93863825
-
AL049840.4
chr14
103694516
103695050
-
AP000317.2
chr21
34073592
34360033
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00662
chr19
27681072
27794005
-
LINC01184
chr5
127939152
128083172
-
MALAT1
chr11
65497688
65506516
+
MCM3AP-AS1
chr21
46229196
46259390
+
NUTM2A-AS1
chr10
87201647
87342612
-
NUTM2B-AS1
chr10
79661394
79826594
-
OIP5-AS1
chr15
41283990
41309737
+
RRN3P2
chr16
29074976
29116718
+
SNHG1
chr11
62851984
62855953
-
SNHG16
chr17
76557764
76565348
+
ZSCAN16-AS1
chr6
28015122
28137293
-
Display:



Experiment Detail

GEO ID:GSE135119
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19117
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2346
Sample treatment protocol:NA
RNA Extract protocol:Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit.
RNA library preparation protocol:Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.



Reference

PMID:31664087
Title:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Author:Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H
Journal:Sci Rep. 2019 Oct 29;9(1):15483.
Description:we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.