exRNAdisease

Entry Detail

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General Information

Database ID: exR0267559 RNA Name: hsa-miR-455-3p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 114209487 End Site(bp): 114209507 External Links: hsa-miR-455-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACKR3 chr2 236567787 236582354 + COL18A1 chr21 45405165 45513720 + DMWD chr19 45782947 45792845 - IGFBP4 chr17 40443450 40457725 + MEPCE chr7 100428790 100434118 + NFIB chr9 14081843 14398983 - PGRMC1 chrX 119236245 119244466 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001791 chr8 38879161 38880844 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0001368 chr3 183361267 183390272 + hsa_circ_0000494 chr13 76134888 76143643 + hsa_circ_0000106 chr1 111690263 111703918 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC021078.1 chr5 149494314 149504670 - AC074117.1 chr2 27356246 27367622 + AC144548.1 chr12 110387463 110445548 - AL137782.1 chr13 75549773 75807120 + DICER1-AS1 chr14 95157645 95181475 + DLEU2 chr13 49956670 50125720 - MIR29B2CHG chr1 207801518 207879115 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.