exRNAdisease

Entry Detail

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General Information

Database ID: exR0267666 RNA Name: hsa-miR-4700-3p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 120723233 End Site(bp): 120723258 External Links: hsa-miR-4700-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand GAPDH chr12 6534512 6538374 + PARP1 chr1 226360691 226408093 - SEC61A1 chr3 128051641 128071683 + TTLL12 chr22 43166622 43187134 - UNC119B chr12 120710458 120723640 + CAMTA2 chr17 4967992 4987675 - FBXO2 chr1 11637018 11655785 - HADH chr4 107989714 108035175 + KDM5B chr1 202724495 202808487 - ORMDL1 chr2 189770267 189784364 - PDIA6 chr2 10783391 10837977 - RPL34 chr4 108620566 108630412 + TINAGL1 chr1 31576485 31587686 + TPT1 chr13 45333471 45341370 - WDR1 chr4 10074339 10116949 - miRNA targets: NA circRNA targets: NA lncRNA targets: NA Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.