exRNAdisease

Entry Detail

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General Information

Database ID: exR0267838 RNA Name: hsa-miR-488-3p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 177029374 End Site(bp): 177029394 External Links: hsa-miR-488-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BCL7A chr12 122019422 122062044 + CHD2 chr15 92900189 93027996 + CYB5B chr16 69424619 69466264 + EGFR chr7 55019017 55211628 + MAN1A1 chr6 119177205 119349761 - MECOM chr3 169083499 169663775 - PHC3 chr3 170086732 170181749 - PLPP3 chr1 56494761 56645301 - SF3A1 chr22 30331988 30356919 - SYAP1 chrX 16719612 16765340 + YWHAB chr20 44885702 44908532 + ZNF704 chr8 80628451 80874781 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001434 chr4 106345352 106377902 - hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AL049543.1 chr6 28587378 28591747 + MIR497HG chr17 7015818 7019659 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG1 chr11 62851984 62855953 - SNHG16 chr17 76557764 76565348 + TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.