exRNAdisease

Entry Detail

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General Information

Database ID: exR0267845 RNA Name: hsa-miR-491-5p RNA Type: miRNA Chromosome: chr9 Starnd: + Coordinate: Start Site(bp): 20716120 End Site(bp): 20716141 External Links: hsa-miR-491-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand IGFBP4 chr17 40443450 40457725 + SRF chr6 43171269 43181506 + CDR2L chr17 74987632 75005800 + CENPB chr20 3783851 3786740 - RBFOX2 chr22 35738736 36028824 - SPRED2 chr2 65310851 65432637 - PHB2 chr12 6965327 6970753 - PTPRU chr1 29236516 29326813 + PTBP3 chr9 112217716 112333667 - SLC6A6 chr3 14402576 14489349 + SNAI1 chr20 49982980 49988886 + NDST1 chr5 150485818 150558211 + PPP4C chr16 30075978 30085376 + LIMD2 chr17 63695888 63701172 - TTPAL chr20 44475874 44494603 + SAMD4B chr19 39342396 39385710 + QSOX2 chr9 136206333 136245812 - C19orf47 chr19 40319536 40348527 - ZNF574 chr19 42068477 42081552 + PDXP chr22 37658723 37666932 + MEF2D chr1 156463727 156500779 - TP53 chr17 7661779 7687550 - ATXN7L3 chr17 44191805 44200113 - CPSF7 chr11 61402641 61430031 - CD151 chr11 832887 839831 + DIRAS1 chr19 2714567 2721372 - COL4A2 chr13 110305812 110513209 + NOTCH2 chr1 119911553 120100779 - INTS2 chr17 61865367 61928016 - HDGF chr1 156742109 156766925 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000128 chr1 151139409 151139890 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC016876.2 chr17 7581964 7584086 - AC023509.1 chr12 53441741 53467528 + AC069281.2 chr7 100572232 100578700 - AL355987.2 chr9 136800366 136829466 + AL645608.6 chr1 904834 915976 + H19 chr11 1995176 2001470 - LINC01278 chrX 63222993 63561095 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + PCBP2-OT1 chr12 53464468 53465057 + VPS9D1-AS1 chr16 89711856 89718165 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.