Entry Detail



General Information

Database ID:exR0267896
RNA Name:hsa-miR-5047
RNA Type:miRNA
Chromosome:chr17
Starnd:-
Coordinate:
Start Site(bp):64501230End Site(bp):64501250
External Links:hsa-miR-5047



Disease Information

Disease Name:Cystic Fibrosis
Disease Category:Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH ID:D003550
Type:Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Alias:Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas



Expression Detail

GEO ID:GSE135119
Description:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Experimental Design:Disease vs Control
Case Disease Type:Cystic Fibrosis
Case Disease SubType:NA
Case Sample:Cystic Fibrosis
Control Sample:Healthy
Number of Case:5
Number of Control:5
Number of Samples:10





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
DDX5
chr17
64498254
64508199
-
FKBP4
chr12
2794970
2805423
+
ASF1A
chr6
118894152
118909171
+
GM2A
chr5
151212150
151270440
+
U2AF2
chr19
55654146
55674715
+
YWHAQ
chr2
9583967
9630997
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001225
chr22
36684772
36684943
-
hsa_circ_0001880
chr9
110084263
110087285
+
hsa_circ_0000018
chr1
15860731
15863309
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC015871.3
chr15
79920195
79922455
-
AC018521.1
chr17
47945424
47981736
+
AC025171.4
chr5
43061395
43062441
+
AC067930.1
chr8
143579636
143580670
+
AC245033.4
chr15
82533175
82540008
-
DANCR
chr4
52712404
52720351
+
JPX
chrX
73944182
74070408
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00894
chrX
149938613
150224580
+
MUC20-OT1
chr3
195658062
195739964
+
NEAT1
chr11
65422774
65445540
+
NNT-AS1
chr5
43571594
43603230
-
SNHG12
chr1
28578538
28583132
-
SNHG16
chr17
76557764
76565348
+
ZFAS1
chr20
49278178
49299600
+
Display:



Experiment Detail

GEO ID:GSE135119
Sample Source:Blood
Source Fraction:Plasma
Platform:GPL19117
Method:Microarray
Num of detected RNA Type:1
Num of detected RNAs of this Type:2346
Sample treatment protocol:NA
RNA Extract protocol:Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit.
RNA library preparation protocol:Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.



Reference

PMID:31664087
Title:Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis
Author:Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H
Journal:Sci Rep. 2019 Oct 29;9(1):15483.
Description:we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.