exRNAdisease

Entry Detail

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General Information

Database ID: exR0267916 RNA Name: hsa-miR-5094 RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 89850690 End Site(bp): 89850711 External Links: hsa-miR-5094

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ZNHIT3 chr17 36486629 36499310 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001159 chr20 40161688 40179999 - hsa_circ_0000698 chr16 47531309 47549512 + hsa_circ_0001445 chr4 144464661 144465125 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001667 chr7 810107 814799 + hsa_circ_0001376 chr3 194169185 194175121 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC074117.1 chr2 27356246 27367622 + AL356488.2 chr1 109100193 109100619 + AL359091.1 chr9 128392007 128393510 - DSCAM-AS1 chr21 40383083 40385358 + FTX chrX 73940435 74293574 - GAS5 chr1 173858559 173868882 - NEAT1 chr11 65422774 65445540 + NUTM2B-AS1 chr10 79661394 79826594 - PDCD4-AS1 chr10 110869868 110872233 - SNHG3 chr1 28505980 28510892 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.