exRNAdisease

Entry Detail

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General Information

Database ID: exR0268232 RNA Name: hsa-miR-629-5p RNA Type: miRNA Chromosome: chr15 Starnd: - Coordinate: Start Site(bp): 70079427 End Site(bp): 70079447 External Links: hsa-miR-629-5p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BAZ2A chr12 56595596 56636816 - CBX2 chr17 79778148 79787983 + CBX3 chr7 26201162 26213607 + COL4A1 chr13 110148963 110307157 - DENND5B chr12 31382226 31591136 - GRB10 chr7 50590063 50793462 - HDLBP chr2 241227264 241317061 - LDLR chr19 11089462 11133820 + MCM3 chr6 52264014 52284881 - MSI1 chr12 120341330 120369164 - NOLC1 chr10 102152176 102163871 + PA2G4 chr12 56104537 56113910 + PHF12 chr17 28905250 28951771 - PRR12 chr19 49591182 49626439 + RSU1 chr10 16590611 16817463 - SH3KBP1 chrX 19533977 19887600 - SH3PXD2A chr10 103594027 103855543 - TULP4 chr6 158232236 158511828 + UBN2 chr7 139230356 139308236 + WIPF2 chr17 40219304 40284136 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001230 chr22 38895404 38897285 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC021078.1 chr5 149494314 149504670 - NEAT1 chr11 65422774 65445540 + U62317.3 chr22 50597152 50597599 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.