exRNAdisease

Entry Detail

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General Information

Database ID: exR0268561 RNA Name: hsa-miR-6835-3p RNA Type: miRNA Chromosome: chr6 Starnd: + Coordinate: Start Site(bp): 34240714 End Site(bp): 34240736 External Links: hsa-miR-6835-3p

Disease Information

Disease Name: Cystic Fibrosis Disease Category: Congenital, Hereditary, and Neonatal Diseases and Abnormalities MeSH ID: D003550 Type: Diseases Category/Congenital, Hereditary, and Neonatal Diseases and Abnormalities Alias: Fibrosis, Cystic//Mucoviscidosis//Pulmonary Cystic Fibrosis//Cystic Fibrosis, Pulmonary//Pancreatic Cystic Fibrosis//Cystic Fibrosis, Pancreatic//Fibrocystic Disease of Pancreas//Pancreas Fibrocystic Disease//Pancreas Fibrocystic Diseases//Cystic Fibrosis of Pancreas

Expression Detail

GEO ID: GSE135119 Description: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Experimental Design: Disease vs Control Case Disease Type: Cystic Fibrosis Case Disease SubType: NA Case Sample: Cystic Fibrosis Control Sample: Healthy Number of Case: 5 Number of Control: 5 Number of Samples: 10

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand HMGA1 chr6 34236873 34246231 + SASH1 chr6 148272304 148552048 + HAPLN1 chr5 83637805 83720855 - MAMDC2 chr9 70043848 70226972 + PABPN1 chr14 23321289 23326185 + PTPRF chr1 43525187 43623666 + PUM1 chr1 30931506 31065991 - ZBTB32 chr19 35704558 35717038 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0000018 chr1 15860731 15863309 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC011815.1 chr18 35280867 35290201 - AC020978.7 chr16 68224713 68227734 + AC021078.1 chr5 149494314 149504670 - AL137129.1 chr14 61734138 61776260 + AL158825.2 chr9 75009828 75016036 - FGD5-AS1 chr3 14920347 14948424 - KCNQ1OT1 chr11 2608328 2699994 - MIR17HG chr13 91347820 91354579 + MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + TERC chr3 169764520 169765060 - XIST chrX 73820649 73852723 - ZFAS1 chr20 49278178 49299600 + Display:

Experiment Detail

GEO ID: GSE135119 Sample Source: Blood Source Fraction: Plasma Platform: GPL19117 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 2346 Sample treatment protocol: NA RNA Extract protocol: Frozen samples; Mixture with Trizol Reagent followed by extraction with RNA Clean and Concentrator kit. RNA library preparation protocol: Using the Affymetrix GeneChip miRNA 4.0 array, 8ul of plasma from each sample was labelled using FlashTag Biotin RNA Labelling kit.

Reference

PMID: 31664087 Title: Microarray profiling identifies extracellular circulating miRNAs dysregulated in cystic fibrosis Author: Ideozu JE, Zhang X, Rangaraj V, McColley S, Levy H Journal: Sci Rep. 2019 Oct 29;9(1):15483. Description: we employed microarray technology to identify aberrantly expressed plasma ECmiRNAs in CF and elucidate the functional relevance of their targets.