exRNAdisease

Entry Detail

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General Information

Database ID: exR0268861 RNA Name: hsa-let-7b-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 46113691 End Site(bp): 46113712 External Links: hsa-let-7b-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TRIM65 chr17 75880335 75896951 - C19orf53 chr19 13774456 13778773 + C16orf58 chr16 31489471 31509309 - TPP1 chr11 6612768 6619448 - TBC1D13 chr9 128787253 128810430 + MARCKSL1 chr1 32333839 32336233 - TECPR2 chr14 102362941 102502477 + TNRC6B chr22 40044817 40335808 + LRIG3 chr12 58872149 58920522 - ARHGAP28 chr18 6729718 6915716 + BACH1 chr21 29194071 29630751 + LIMD1 chr3 45555394 45686341 + BLOC1S6 chr15 45587214 45615945 + PPARA chr22 46150521 46243756 + RTKN chr2 74425835 74442422 - HMGA2 chr12 65824131 65966295 + YOD1 chr1 207043849 207052980 - GOLGA4 chr3 37243177 37366751 + ZNF652 chr17 49289206 49362473 - MIER3 chr5 56919602 56971675 - AP1S1 chr7 101154456 101161596 + RANBP2 chr2 108719482 108785809 + RAB40C chr16 589357 629272 + PDPR chr16 70113626 70162537 + TRAPPC10 chr21 44012309 44106552 + COIL chr17 56938199 56961050 - BCAM chr19 44809071 44821421 + PHC3 chr3 170086732 170181749 - CREM chr10 35126791 35212958 + ACP1 chr2 264140 278283 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000247 chr10 74474868 74475660 + hsa_circ_0000987 chr2 30748452 30756180 + hsa_circ_0000246 chr10 74468040 74475660 + hsa_circ_0000018 chr1 15860731 15863309 + hsa_circ_0000038 chr1 28800065 28802803 + hsa_circ_0000799 chr17 65941524 65972074 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC006064.5 chr12 6510275 6510522 + AC074117.1 chr2 27356246 27367622 + AC109460.3 chr16 28974804 28990775 + AC124045.1 chr3 44667412 44669364 + AP000766.1 chr11 107312132 107316271 - ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - KCNQ1OT1 chr11 2608328 2699994 - LINC00265 chr7 39733430 39793092 + LINC02381 chr12 54126082 54147485 + MIRLET7BHG chr22 46053869 46113928 + NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - SNHG16 chr17 76557764 76565348 + SNHG4 chr5 139274102 139284899 + TMPO-AS1 chr12 98512973 98516422 - XIST chrX 73820649 73852723 - ZNF436-AS1 chr1 23368997 23371839 + Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.