Entry Detail


General Information

Database ID:exR0268885
RNA Name:hsa-miR-126-5p
RNA Type:miRNA
Chromosome:chr9
Starnd:+
Coordinate:
Start Site(bp):136670616End Site(bp):136670636
External Links:hsa-miR-126-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001731
chr7
100731990
100738448
+
hsa_circ_0000598
chr15
45009906
45009989
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001146
chr20
34241449
34246936
-
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC009032.1
chr16
69632141
69632571
+
AC010655.4
chr7
128455840
128493859
+
AC078846.1
chr7
129604548
129611630
-
AC124798.1
chr11
17380649
17383531
+
FGD5-AS1
chr3
14920347
14948424
-
HOTAIR
chr12
53962308
53974956
-
LINC00667
chr18
5237826
5290608
+
LINC00943
chr12
126723412
126749027
+
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NUTM2B-AS1
chr10
79661394
79826594
-
OIP5-AS1
chr15
41283990
41309737
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.