Entry Detail


General Information

Database ID:exR0268891
RNA Name:hsa-miR-1301-3p
RNA Type:miRNA
Chromosome:chr2
Starnd:-
Coordinate:
Start Site(bp):25328651End Site(bp):25328674
External Links:hsa-miR-1301-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:NA
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001225
chr22
36684772
36684943
-
hsa_circ_0001880
chr9
110084263
110087285
+
hsa_circ_0000799
chr17
65941524
65972074
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC015871.3
chr15
79920195
79922455
-
AC018521.1
chr17
47945424
47981736
+
AC025171.4
chr5
43061395
43062441
+
AC067930.1
chr8
143579636
143580670
+
AC245033.4
chr15
82533175
82540008
-
DANCR
chr4
52712404
52720351
+
JPX
chrX
73944182
74070408
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00894
chrX
149938613
150224580
+
MUC20-OT1
chr3
195658062
195739964
+
NEAT1
chr11
65422774
65445540
+
NNT-AS1
chr5
43571594
43603230
-
PVT1
chr8
127794526
128187101
+
SNHG12
chr1
28578538
28583132
-
SNHG16
chr17
76557764
76565348
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.