Entry Detail


General Information

Database ID:exR0268900
RNA Name:hsa-miR-139-5p
RNA Type:miRNA
Chromosome:chr11
Starnd:-
Coordinate:
Start Site(bp):72615102End Site(bp):72615124
External Links:hsa-miR-139-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
AP3M1
chr10
74120255
74151063
-
ARIH1
chr15
72474330
72602987
+
FBN2
chr5
128257909
128659185
-
ISG20L2
chr1
156721891
156728799
-
ITGA3
chr17
50055968
50090481
+
JPT2
chr16
1678256
1702280
+
KLHL28
chr14
44924319
45042322
-
LRP8
chr1
53242364
53328469
-
MKLN1
chr7
131110096
131496632
+
SLC26A2
chr5
149960758
149993455
+
SLC31A1
chr9
113221544
113264492
+
TGOLN2
chr2
85318020
85328296
-
TPM4
chr19
16067021
16103002
+
WIPF2
chr17
40219304
40284136
+
YWHAB
chr20
44885702
44908532
+
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC068768.1
chr12
123262060
123262402
+
AC084082.1
chr8
66112667
66126632
+
AL132655.1
chr20
58833809
58836529
-
NEAT1
chr11
65422774
65445540
+
NUTM2A-AS1
chr10
87201647
87342612
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.