exRNAdisease

Entry Detail

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General Information

Database ID: exR0268903 RNA Name: hsa-miR-142-3p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 58331245 End Site(bp): 58331267 External Links: hsa-miR-142-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand BLOC1S6 chr15 45587214 45615945 + BOD1 chr5 173607145 173616659 - CUL5 chr11 108008898 108107761 + ETFRF1 chr12 25195216 25209645 + SEMA7A chr15 74409289 74433958 - TNRC6B chr22 40044817 40335808 + ZNF676 chr19 22179089 22215801 - AL139011.2 chr1 160216800 160285130 - B2M chr15 44711487 44718877 + CCDC126 chr7 23597382 23644708 + EEF1A1 chr6 73515750 73523797 - MAST2 chr1 45786987 46036122 + MBD3 chr19 1573596 1592865 - MRPL18 chr6 159789812 159798436 + NDUFA2 chr5 140638740 140647785 - PEX19 chr1 160276812 160286348 - PRDX1 chr1 45511036 45523047 - RPL27 chr17 42998273 43002959 + SLC35F5 chr2 113705011 113756693 - SPDL1 chr5 169583636 169604778 + TMSB4X chrX 12975110 12977227 + VPS53 chr17 508668 721717 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000120 chr1 117944807 118009049 + hsa_circ_0001387 chr4 1902352 1936989 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004687.1 chr17 58330884 58332508 - AC011815.1 chr18 35280867 35290201 - AC126365.1 chr17 20788071 20789584 + FGD5-AS1 chr3 14920347 14948424 - MALAT1 chr11 65497688 65506516 + NEAT1 chr11 65422774 65445540 + AC138761.1 chr17 22266395 22288301 + Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.