Entry Detail


General Information

Database ID:exR0268908
RNA Name:hsa-miR-145-5p
RNA Type:miRNA
Chromosome:chr5
Starnd:+
Coordinate:
Start Site(bp):149430661End Site(bp):149430683
External Links:hsa-miR-145-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACBD5
chr10
27195214
27242130
-
ATP9A
chr20
51596514
51768390
-
BAZ1B
chr7
73440406
73522293
-
CARMIL1
chr6
25279078
25620530
+
CCNJ
chr10
96043394
96060870
+
MYRF
chr11
61752642
61788518
+
PLEKHM1
chr17
45435900
45490749
-
PPP1R9B
chr17
50133737
50150677
-
RAD23B
chr9
107283137
107332192
+
ZNF28
chr19
52797408
52857600
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001454
chr4
154524454
154533552
+
hsa_circ_0000540
chr14
55799534
55821940
+
hsa_circ_0001731
chr7
100731990
100738448
+
hsa_circ_0001492
chr5
65284462
65290692
+
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000943
chr19
47421744
47440665
+
hsa_circ_0001168
chr20
47691321
47707559
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC006064.5
chr12
6510275
6510522
+
AC016876.2
chr17
7581964
7584086
-
AC023509.1
chr12
53441741
53467528
+
AC105339.2
chr15
82752884
82757208
+
AC144548.1
chr12
110387463
110445548
-
AL031282.2
chr1
1702736
1737688
-
JPX
chrX
73944182
74070408
+
KCNQ1OT1
chr11
2608328
2699994
-
LINC00852
chr3
10284419
10285746
+
MALAT1
chr11
65497688
65506516
+
MEG3
chr14
100779410
100861031
+
SNHG1
chr11
62851984
62855953
-
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.