Entry Detail


General Information

Database ID:exR0268915
RNA Name:hsa-miR-151a-3p
RNA Type:miRNA
Chromosome:chr8
Starnd:-
Coordinate:
Start Site(bp):140732587End Site(bp):140732607
External Links:hsa-miR-151a-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACP1
chr2
264140
278283
+
PCDHA1
chr5
140786136
141012347
+
PCDHA10
chr5
140855883
141012347
+
PCDHA11
chr5
140868183
141012344
+
PCDHA12
chr5
140875302
141012347
+
PCDHA13
chr5
140882124
141012347
+
PCDHA2
chr5
140794852
141012347
+
PCDHA3
chr5
140801028
141012347
+
PCDHA4
chr5
140806929
141012347
+
PCDHA5
chr5
140821604
141012347
+
PCDHA6
chr5
140827958
141012347
+
PCDHA7
chr5
140834248
141012347
+
PCDHA8
chr5
140841187
141012347
+
PCDHA9
chr5
140847463
141012344
+
PCDHAC1
chr5
140926369
141012344
+
PCDHAC2
chr5
140966470
141012347
+
STRBP
chr9
123109500
123268586
-
miRNA targets:NA
circRNA targets:NA
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC044784.1
chr10
8970125
8973468
+
AC104794.2
chr2
10083781
10086101
+
AL160006.1
chr1
110058340
110062555
+
SCARNA9
chr11
93721513
93721865
+
TUG1
chr22
30969245
30979395
+
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.