exRNAdisease

Entry Detail

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General Information

Database ID: exR0268934 RNA Name: hsa-miR-185-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 20033153 End Site(bp): 20033174 External Links: hsa-miR-185-5p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TFAP2A chr6 10393186 10419659 - SSH2 chr17 29625938 29930276 - ZBTB4 chr17 7459366 7484263 - CTSA chr20 45890144 45898820 + TSPAN14 chr10 80454166 80533124 + ACVR1B chr12 51951699 51997078 + GRB2 chr17 75318076 75405709 - RAB5A chr3 19947097 19985175 + RAB40C chr16 589357 629272 + VPS37B chr12 122865330 122896127 - SLC29A1 chr6 44219553 44234142 + NDRG1 chr8 133237171 133302022 - HDLBP chr2 241227264 241317061 - RSU1 chr10 16590611 16817463 - HADHA chr2 26190635 26244672 - VPS4A chr16 69311350 69326939 + IGF2BP1 chr17 48997385 49056145 + NF1 chr17 31094927 31382116 + SMAD3 chr15 67063763 67195169 + ORAI1 chr12 121626550 121642677 + ADGRG1 chr16 57610652 57665580 + TNRC6B chr22 40044817 40335808 + ZMIZ1 chr10 79068966 79316528 + GOLGA1 chr9 124878275 124948492 - ZBTB38 chr3 141324213 141449792 + SLC29A2 chr11 66362521 66372214 - GATAD2B chr1 153789030 153923360 - GBA2 chr9 35736866 35749228 - OTUD4 chr4 145110838 145180589 - FAM234A chr16 234521 272183 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001658 chr6 157357968 157406039 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC008040.1 chr3 169939353 169966734 - AC021092.1 chr19 44103007 44113183 - LINC01278 chrX 63222993 63561095 - MALAT1 chr11 65497688 65506516 + MIR137HG chr1 97933474 98049863 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.