exRNAdisease

Entry Detail

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General Information

Database ID: exR0268947 RNA Name: hsa-miR-199a-3p RNA Type: miRNA Chromosome: chr1 Starnd: - Coordinate: Start Site(bp): 172144554 End Site(bp): 172144575 External Links: hsa-miR-199a-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand AP3B1 chr5 78000525 78294755 - DUSP5 chr10 110497907 110511533 + E2F3 chr6 20401879 20493714 + EMP1 chr12 13196723 13219941 + PDXDC1 chr16 14974591 15139339 + RBM23 chr14 22893204 22919182 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0000311 chr11 61205096 61205585 + hsa_circ_0001865 chr9 86292641 86293514 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005082.1 chr7 23205787 23208045 + AC005165.1 chr7 25593304 25751032 - AC010542.4 chr16 66549280 66551189 + AC021078.1 chr5 149494314 149504670 - AC079781.5 chr7 97851688 97972985 - AL122035.1 chr14 64422935 64448557 - AL358472.3 chr1 153966516 153966930 + MALAT1 chr11 65497688 65506516 + MIR200CHG chr12 6963246 6964447 + NEAT1 chr11 65422774 65445540 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + OTUD6B-AS1 chr8 91059318 91070583 - SCARNA9 chr11 93721513 93721865 + SNHG1 chr11 62851984 62855953 - TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.