Entry Detail



General Information

Database ID:exR0268956
RNA Name:hsa-miR-20a-5p
RNA Type:miRNA
Chromosome:chr13
Starnd:+
Coordinate:
Start Site(bp):91351072End Site(bp):91351094
External Links:hsa-miR-20a-5p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
RIPOR1
chr16
67518418
67546788
+
EIF5A2
chr3
170888418
170908644
-
RCCD1
chr15
90954870
90963125
+
FHL1
chrX
136146702
136211359
+
ZFAND4
chr10
45615500
45672780
-
CLOCK
chr4
55427903
55546909
-
NSD1
chr5
177133025
177300215
+
ZDHHC12
chr9
128720870
128724127
-
PXYLP1
chr3
141228726
141367753
+
C9orf40
chr9
74946583
74952912
-
PBXIP1
chr1
154944076
154956123
-
ZNF468
chr19
52838010
52857649
-
ATXN1
chr6
16299112
16761491
-
SCAMP2
chr15
74843730
74873365
-
SLC46A3
chr13
28700064
28718970
-
GNAS
chr20
58839718
58911192
+
MBP
chr18
76978827
77133683
-
AMPD2
chr1
109616104
109632053
+
PXDN
chr2
1631887
1744852
-
WDR37
chr10
1049538
1132384
+
CYLD
chr16
50742050
50801935
+
ZSCAN26
chr6
28267010
28278224
+
STRN3
chr14
30893799
31026401
-
ADARB1
chr21
45073853
45226560
+
KLHL28
chr14
44924319
45042322
-
WASF3
chr13
26557683
26688948
+
BTN3A1
chr6
26402237
26415208
+
CRCP
chr7
66114604
66154568
+
FCF1
chr14
74713144
74738620
+
ARMC8
chr3
138187248
138298384
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001495
chr5
68470703
68471364
+
hsa_circ_0000494
chr13
76134888
76143643
+
hsa_circ_0000018
chr1
15860731
15863309
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC015871.3
chr15
79920195
79922455
-
AC021078.1
chr5
149494314
149504670
-
AC021092.1
chr19
44103007
44113183
-
AC024940.6
chr12
31280422
31280895
-
AC084082.1
chr8
66112667
66126632
+
AC087477.2
chr15
96354237
96405235
+
AC243964.3
chr19
44631573
44725217
-
AL031428.1
chr1
23020147
23088058
-
AL137782.1
chr13
75549773
75807120
+
AL158206.1
chr9
19453209
19455173
+
AL161772.1
chr13
20699307
20703718
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
CKMT2-AS1
chr5
81201341
81301565
-
EPB41L4A-AS1
chr5
112160526
112164818
+
ERICD
chr8
140636281
140638283
+
FGD5-AS1
chr3
14920347
14948424
-
H19
chr11
1995176
2001470
-
HAGLR
chr2
176164051
176188958
-
HOTAIR
chr12
53962308
53974956
-
MALAT1
chr11
65497688
65506516
+
NEAT1
chr11
65422774
65445540
+
NORAD
chr20
36045618
36051018
-
SNHG16
chr17
76557764
76565348
+
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.