Entry Detail


General Information

Database ID:exR0268965
RNA Name:hsa-miR-221-3p
RNA Type:miRNA
Chromosome:chrX
Starnd:-
Coordinate:
Start Site(bp):45746180End Site(bp):45746202
External Links:hsa-miR-221-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ACVR2B
chr3
38453890
38493142
+
AP3M1
chr10
74120255
74151063
-
DNAJC14
chr12
55820960
55830824
-
EFNA1
chr1
155127876
155134899
+
KDSR
chr18
63327726
63367228
-
MPZL1
chr1
167721192
167791919
+
PPIL1
chr6
36854827
36874803
-
TBL1X
chrX
9463295
9741037
+
TUB
chr11
8019244
8106112
+
ZBTB5
chr9
37438102
37465450
-
DDIT4
chr10
72273924
72276036
+
FUS
chr16
31180110
31194871
+
MAPRE1
chr20
32819954
32850405
+
RIPOR2
chr6
24804282
25042170
-
SP4
chr7
21428043
21514822
+
TUBA1B
chr12
49127782
49131397
-
ZNF649
chr19
51889235
51905040
-
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001247
chr22
46125304
46136418
+
hsa_circ_0000670
chr16
9199043
9199243
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC020978.7
chr16
68224713
68227734
+
AC022150.4
chr19
52650437
52653284
-
ARHGAP27P1-BPTFP1-KPNA2P3
chr17
64749663
64781707
-
GAS5
chr1
173858559
173868882
-
NEAT1
chr11
65422774
65445540
+
TUG1
chr22
30969245
30979395
+
TYMSOS
chr18
630886
658340
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.