exRNAdisease

Entry Detail

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General Information

Database ID: exR0268978 RNA Name: hsa-miR-25-3p RNA Type: miRNA Chromosome: chr7 Starnd: - Coordinate: Start Site(bp): 100093571 End Site(bp): 100093592 External Links: hsa-miR-25-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ADCY9 chr16 3953387 4116442 - ARMC1 chr8 65602458 65634217 - BCL9 chr1 147541501 147626216 + CCDC186 chr10 114120862 114174232 - CERK chr22 46684410 46738252 - EIF1AX chrX 20124525 20141838 - EML4 chr2 42169353 42332548 + FNBP4 chr11 47716494 47767443 - ITGAV chr2 186590056 186680901 + MRS2 chr6 24402908 24426194 + MTHFD2 chr2 74198610 74217565 + MYH9 chr22 36281277 36388067 - NFIB chr9 14081843 14398983 - NSMAF chr8 58583508 58659853 - PALLD chr4 168497052 168928457 + PPAT chr4 56393362 56435615 - PUS7 chr7 105439661 105522271 - RBFOX2 chr22 35738736 36028824 - RNF38 chr9 36336396 36487548 - RNF4 chr4 2462220 2625320 + RRN3 chr16 15060022 15094317 - SH3PXD2A chr10 103594027 103855543 - SOX4 chr6 21593751 21598619 + TXLNA chr1 32179675 32198285 + UBE2N chr12 93405673 93441947 - USP21 chr1 161159450 161165723 + XRN1 chr3 142306607 142448062 - TXNRD3 chr3 126607059 126655124 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001005 chr2 53921020 53978078 - hsa_circ_0001414 chr4 56277780 56284152 + hsa_circ_0000126 chr1 150997086 150999803 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC074117.1 chr2 27356246 27367622 + AC130650.2 chr16 14150833 14153235 + DAPK1-IT1 chr9 87553454 87554459 + LINC01128 chr1 825138 859446 + MALAT1 chr11 65497688 65506516 + NORAD chr20 36045618 36051018 - OIP5-AS1 chr15 41283990 41309737 + PITPNA-AS1 chr17 1516931 1518096 + PURPL chr5 27217714 27496994 + SNHG5 chr6 85650491 85678932 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.