exRNAdisease

Entry Detail

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General Information

Database ID: exR0269007 RNA Name: hsa-miR-330-3p RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 45639009 End Site(bp): 45639031 External Links: hsa-miR-330-3p

Disease Information

Disease Name: Chronic Thromboembolic Pulmonary Hypertension Disease Category: Respiratory Tract Diseases MeSH ID: D006976 Type: Diseases Category/Respiratory Tract Diseases Alias: Hypertension, Pulmonary//Pulmonary Hypertension

Expression Detail

GEO ID: GSE138107 Description: Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA Experimental Design: Disease vs Control Case Disease Type: Chronic Thromboembolic Pulmonary Hypertension Case Disease SubType: NA Case Sample: Chronic Thromboembolic Pulmonary Hypertension Control Sample: Control Number of Case: 3 Number of Control: 3 Number of Samples: 6

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ANP32B chr9 97983341 98015943 + ATRX chrX 77504878 77786233 - BCL2L11 chr2 111119378 111168445 + CBX2 chr17 79778148 79787983 + CCSER2 chr10 84328586 84518521 + CRCP chr7 66114604 66154568 + DAG1 chr3 49468703 49535618 + ERLIN1 chr10 100150094 100186033 - GNAI2 chr3 50226292 50259362 + HNRNPAB chr5 178204533 178211163 + MRFAP1 chr4 6640091 6642745 + MTMR12 chr5 32226994 32312987 - NPAT chr11 108157215 108222638 - PFN1 chr17 4945652 4949061 - PKN2 chr1 88684222 88836255 + RAB10 chr2 26034084 26137454 + SNX27 chr1 151612006 151699091 + TNKS chr8 9555912 9782346 + TOMM34 chr20 44942130 44960397 - TRIM25 chr17 56836387 56914080 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000591 chr15 41961025 41962156 + hsa_circ_0000540 chr14 55799534 55821940 + hsa_circ_0001731 chr7 100731990 100738448 + hsa_circ_0001168 chr20 47691321 47707559 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC020978.7 chr16 68224713 68227734 + AC079781.5 chr7 97851688 97972985 - AC124045.1 chr3 44667412 44669364 + AC125257.1 chr17 41848518 41851447 - AL132655.1 chr20 58833809 58836529 - AL137129.1 chr14 61734138 61776260 + AL157392.3 chr10 13631143 13668445 + FGD5-AS1 chr3 14920347 14948424 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + OIP5-AS1 chr15 41283990 41309737 + SNHG25 chr17 64145970 64146476 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE138107 Sample Source: Blood Source Fraction: Exosome Platform: GPL18573 Method: NGS Num of detected RNA Type: 3 Num of detected RNAs of this Type: 359 Sample treatment protocol: Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis. RNA Extract protocol: total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum. RNA library preparation protocol: SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)

Reference

PMID: 31671920 Title: Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA Author: Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C Journal: Biomolecules. 2019 Oct 29;9(11). pii: E666. Description: We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.