Entry Detail



General Information

Database ID:exR0269101
RNA Name:hsa-miR-92b-3p
RNA Type:miRNA
Chromosome:chr1
Starnd:+
Coordinate:
Start Site(bp):155195237End Site(bp):155195258
External Links:hsa-miR-92b-3p



Disease Information

Disease Name:Chronic Thromboembolic Pulmonary Hypertension
Disease Category:Respiratory Tract Diseases
MeSH ID:D006976
Type:Diseases Category/Respiratory Tract Diseases
Alias:Hypertension, Pulmonary//Pulmonary Hypertension



Expression Detail

GEO ID:GSE138107
Description:Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
Experimental Design:Disease vs Control
Case Disease Type:Chronic Thromboembolic Pulmonary Hypertension
Case Disease SubType:NA
Case Sample:Chronic Thromboembolic Pulmonary Hypertension
Control Sample:Control
Number of Case:3
Number of Control:3
Number of Samples:6





Regulatory Relationship

mRNA targets:
Gene SymbolChromosomeStart Site(bp)End Site(bp)Strand
ADCY3
chr2
24819169
24919839
-
ADCY9
chr16
3953387
4116442
-
ADM
chr11
10305073
10307397
+
CCDC186
chr10
114120862
114174232
-
FNBP4
chr11
47716494
47767443
-
KLF4
chr9
107484852
107490482
-
MRPS16
chr10
73248843
73252693
-
MTHFD2
chr2
74198610
74217565
+
NPTX1
chr17
80466834
80477843
-
NSMAF
chr8
58583508
58659853
-
PUS7
chr7
105439661
105522271
-
RBFOX2
chr22
35738736
36028824
-
SH3PXD2A
chr10
103594027
103855543
-
SOX4
chr6
21593751
21598619
+
XRN1
chr3
142306607
142448062
-
POLR2F
chr22
37952607
38041915
+
miRNA targets:NA
circRNA targets:
circRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
hsa_circ_0001005
chr2
53921020
53978078
-
hsa_circ_0001414
chr4
56277780
56284152
+
hsa_circ_0000126
chr1
150997086
150999803
+
lncRNA targets:
lncRNA SymbolChromosomeStart Site(bp)End Site(bp)Strand
AC005394.2
chr19
28435388
28727680
-
AC074117.1
chr2
27356246
27367622
+
AC130650.2
chr16
14150833
14153235
+
DAPK1-IT1
chr9
87553454
87554459
+
LINC01128
chr1
825138
859446
+
MALAT1
chr11
65497688
65506516
+
NORAD
chr20
36045618
36051018
-
OIP5-AS1
chr15
41283990
41309737
+
PITPNA-AS1
chr17
1516931
1518096
+
PURPL
chr5
27217714
27496994
+
SNHG5
chr6
85650491
85678932
-
XIST
chrX
73820649
73852723
-
Display:



Experiment Detail

GEO ID:GSE138107
Sample Source:Blood
Source Fraction:Exosome
Platform:GPL18573
Method:NGS
Num of detected RNA Type:3
Num of detected RNAs of this Type:359
Sample treatment protocol:Serum was collected by centrifugation at 3000×g for 10 min and samples were then frozen at -80°C until analysis.
RNA Extract protocol:total RNA RNA was isolated using the ExoRNeasy Midi kit (Qiagen, Hilden, Germany) with a starting volume of 100 ul serum.
RNA library preparation protocol:SncRNA libraries were prepared using the TrueQuant technology (GenXPro, Frankfurt am Main, Germany)



Reference

PMID:31671920
Title:Non-Invasive Approach for Evaluation of Pulmonary Hypertension Using Extracellular Vesicle-Associated Small Non-Coding RNA
Author:Lipps C, Northe P, Figueiredo R, Rohde M, Brahmer A, Kr?mer-Albers EM, Liebetrau C, Wiedenroth CB, Mayer E, Kriechbaum SD, D?rr O, Nef H, Hamm CW, Keller T, Troidl C
Journal:Biomolecules. 2019 Oct 29;9(11). pii: E666.
Description:We aimed to determine whether extracellular vesicles isolated from patients with pulmonary hypertension show a disease specific signature of small non-coding RNAs and thus have the potential to serve as diagnostic and prognostic biomarkers.