exRNAdisease

Entry Detail

General Information

Database ID:

exR0275171

RNA Name:

hsa-miR-101-3p

RNA Type:

miRNA

Chromosome:

chr1

Starnd:

-

Coordinate:

Start Site(bp):

65058442

End Site(bp):

65058462

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AEN	chr15	88621337	88632281	+
CA12	chr15	63321378	63381846	-
CNOT11	chr2	101252886	101270316	+
CPEB2	chr4	15002674	15070153	+
DIP2B	chr12	50504985	50748657	+
GABPB1	chr15	50275392	50355408	-
JUNB	chr19	12791486	12793315	+
PLS1	chr3	142596393	142713664	+
USP47	chr11	11841423	11961887	+
WDCP	chr2	24029347	24049575	-

miRNA targets:

NA

circRNA targets:

NA

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC004687.1	chr17	58330884	58332508	-
AC024940.6	chr12	31280422	31280895	-
AC145207.5	chr17	81878425	81881106	-
AC243964.3	chr19	44631573	44725217	-
AC245297.2	chr1	149264252	149264816	+
EBLN3P	chr9	37079645	37090928	+
MALAT1	chr11	65497688	65506516	+
NEAT1	chr11	65422774	65445540	+
SNHG1	chr11	62851984	62855953	-
SNHG6	chr8	66921684	66926398	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.