exRNAdisease

Entry Detail

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General Information

Database ID: exR0275188 RNA Name: hsa-miR-1181 RNA Type: miRNA Chromosome: chr19 Starnd: - Coordinate: Start Site(bp): 10403505 End Site(bp): 10403525 External Links: hsa-miR-1181

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand CDC37 chr19 10391133 10420121 - CHD7 chr8 60678740 60868028 + IRS2 chr13 109752695 109786583 - MAZ chr16 29806106 29811164 + PIM1 chr6 37170152 37175428 + RRP1B chr21 43659560 43696079 + ZMIZ1 chr10 79068966 79316528 + CAMK4 chr5 111223653 111494886 + ELF1 chr13 40931924 41061440 - GNAS chr20 58839718 58911192 + GSPT1 chr16 11868128 11916082 - HNRNPA0 chr5 137745651 137754363 - HNRNPUL2 chr11 62712630 62727457 - HNRNPUL2-BSCL2 chr11 62690275 62727384 - IMMT chr2 86143932 86195770 - MDFIC chr7 114922154 115019202 + PRKAA2 chr1 56645314 56715335 + RAB21 chr12 71754863 71800286 + RALY chr20 33993646 34108308 + SLC4A4 chr4 71062667 71572087 + SOX1 chr13 112067149 112071706 + SPINT2 chr19 38244035 38292615 + TMEFF1 chr9 100473149 100577636 + TTC3 chr21 37073226 37203112 + U2AF1 chr21 43092956 43107587 - U2AF1L5 chr21 6484623 6499261 - UBE2D2 chr5 139526431 139628434 + ZNF282 chr7 149195546 149226238 + miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007216.1 chr16 11976851 11977850 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.