exRNAdisease

General Information

Database ID:

exR0275204

RNA Name:

hsa-miR-122-5p

RNA Type:

miRNA

Chromosome:

chr18

Starnd:

Coordinate:

Start Site(bp):

58451088

End Site(bp):

58451109

External Links:

Disease Information

Disease Name:	Advanced Adenoma
Disease Category:	Cancers
MeSH ID:	D000236
Type:	Neoplasms/Neoplasms, Glandular and Epithelial
Alias:	Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID:	GSE25609
Description:	Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening
Experimental Design:	Cancer vs Control
Case Disease Type:	Advanced Adenoma
Case Disease SubType:	NA
Case Sample:	Advanced Adenoma Post surgery
Control Sample:	Control
Number of Case:	20
Number of Control:	20
Number of Samples:	40

Regulatory Relationship

mRNA targets:

Gene Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
MSI2	chr17	57255851	57684689	+
FAM102A	chr9	127940582	127980989	-
NAGK	chr2	71064344	71079808	+
SPRED2	chr2	65310851	65432637	-
HGSNAT	chr8	43140464	43202855	+
PPDPF	chr20	63520765	63522206	+
SH3GL1	chr19	4360370	4400547	-
SETD1A	chr16	30957754	30984664	+
PEA15	chr1	160205337	160215376	+
C19orf54	chr19	40740856	40751553	-
PIP4K2A	chr10	22534854	22714578	-
RPRD1B	chr20	38033725	38127780	+
CACNG4	chr17	66964707	67033398	+
SOX11	chr2	5692384	5701385	+
IGFBP5	chr2	216672105	216695549	-
RAB1B	chr11	66268590	66277492	+
CSRP1	chr1	201483530	201509456	-
VTI1A	chr10	112446998	112818744	+
ZNF3	chr7	100064033	100082548	-
NHLRC3	chr13	39038306	39050109	+
ZNF614	chr19	52012765	52030240	-
NDOR1	chr9	137205685	137217009	+
ALDOA	chr16	30064164	30070457	+
GRK3	chr22	25564675	25729294	+
C19orf47	chr19	40319536	40348527	-
SLC9A1	chr1	27098809	27166981	-
STK4	chr20	44966479	45080021	+
IER2	chr19	13150411	13154911	+
PRR12	chr19	49591182	49626439	+
KRT7	chr12	52232520	52252186	+

miRNA targets:

circRNA targets:

lncRNA targets:

lncRNA Symbol	Chromosome	Start Site(bp)	End Site(bp)	Strand
AC021092.1	chr19	44103007	44113183	-
AC103702.1	chr17	48579630	48582259	-
AL358472.3	chr1	153966516	153966930	+
AL645465.1	chr1	244375100	244409592	-
DSCAM-AS1	chr21	40383083	40385358	+
NEAT1	chr11	65422774	65445540	+
SNHG7	chr9	136721366	136728184	-
XIST	chrX	73820649	73852723	-

Display:

Experiment Detail

GEO ID:	GSE25609
Sample Source:	Blood
Source Fraction:	Plasma
Platform:	GPL8179
Method:	Microarray
Num of detected RNA Type:	1
Num of detected RNAs of this Type:	826
Sample treatment protocol:	Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components.
RNA Extract protocol:	NA
RNA library preparation protocol:	Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID:	23267864
Title:	Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study
Author:	Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M
Journal:	Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3.
Description:	We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.