exRNAdisease

Entry Detail

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General Information

Database ID: exR0275206 RNA Name: hsa-miR-1224-5p RNA Type: miRNA Chromosome: chr3 Starnd: + Coordinate: Start Site(bp): 184241405 End Site(bp): 184241423 External Links: hsa-miR-1224-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ARF3 chr12 48935723 48957487 - DHCR7 chr11 71428193 71452868 - ZNF621 chr3 40524878 40574685 + SEC14L1 chr17 77088749 77217101 + EMC10 chr19 50476400 50490870 + RACGAP1 chr12 49976923 50033136 - THBD chr20 23045633 23049672 - ENSA chr1 150600851 150629612 - SLC9A3R1 chr17 74748628 74769353 + STK4 chr20 44966479 45080021 + LDOC1 chrX 141111605 141177129 - UBL5 chr19 9827892 9830115 + HOXB8 chr17 48611377 48615292 - ANKRD52 chr12 56237807 56258384 - TRAM2 chr6 52497408 52577060 - RNF157 chr17 76142465 76240493 - STC1 chr8 23841929 23854806 - LMBR1 chr7 156668946 156893216 - CALU chr7 128739292 128773400 + ATP6V1A chr3 113747033 113812056 + KIAA1522 chr1 32741830 32774970 + IKBKB chr8 42271302 42332653 + XPO7 chr8 21919662 22006585 + MIER3 chr5 56919602 56971675 - DYRK1B chr19 39825350 39834201 - TBC1D20 chr20 435480 462543 - MAPKAPK2 chr1 206684944 206734283 + OPA3 chr19 45527427 45602212 - AK2 chr1 33007940 33080996 - FYCO1 chr3 45917899 45995824 - miRNA targets: NA circRNA targets: NA lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC009133.5 chr16 29808679 29812227 + AP000766.1 chr11 107312132 107316271 - NEAT1 chr11 65422774 65445540 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.