exRNAdisease

Entry Detail

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General Information

Database ID: exR0275337 RNA Name: hsa-miR-147a RNA Type: miRNA Chromosome: chr9 Starnd: - Coordinate: Start Site(bp): 120244985 End Site(bp): 120245004 External Links: hsa-miR-147a

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TWF1 chr12 43793723 43806375 - GLYR1 chr16 4803203 4847288 - PLPP6 chr9 4662294 4665258 + USP37 chr2 218450251 218568351 - CTSD chr11 1752755 1764573 - NUP58 chr13 25301556 25349800 + JARID2 chr6 15246069 15522042 + SCARB1 chr12 124776856 124882668 - MGRN1 chr16 4616493 4690974 + CRKL chr22 20917407 20953747 + SIPA1L3 chr19 37907208 38208369 + TIMP3 chr22 32801701 32863043 + SNAI2 chr8 48917598 48921740 - FAM13A chr4 88725955 89111398 - ZNF618 chr9 113876282 114056591 + SMIM12 chr1 34712737 34859755 - CCND1 chr11 69641156 69654474 + FOXK2 chr17 82519713 82644662 + SLC7A1 chr13 29509414 29595688 - ATP11A chr13 112690329 112887168 + PSME3 chr17 42824385 42843760 + WIZ chr19 15419978 15449956 - PURA chr5 140107777 140125619 + STARD7 chr2 96184859 96208825 - OSBPL9 chr1 51577179 51798427 + PIK3C2A chr11 17077730 17207983 - NKIRAS2 chr17 42011382 42025644 + LIMD1 chr3 45555394 45686341 + TNFRSF10B chr8 23020133 23069031 - ARHGAP35 chr19 46860997 47005077 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0000816 chr17 80521229 80526077 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC004951.4 chr7 43951910 44019151 - AC010442.1 chr5 466124 473098 - AL355987.2 chr9 136800366 136829466 + DSCAM-AS1 chr21 40383083 40385358 + KCNQ1OT1 chr11 2608328 2699994 - MIR503HG chrX 134543119 134546642 - NEAT1 chr11 65422774 65445540 + POLR2J4 chr7 43940895 44019175 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.