exRNAdisease

Entry Detail

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General Information

Database ID: exR0275341 RNA Name: hsa-miR-148b-3p RNA Type: miRNA Chromosome: chr12 Starnd: + Coordinate: Start Site(bp): 54337278 End Site(bp): 54337299 External Links: hsa-miR-148b-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand E2F1 chr20 33675477 33686385 - EMP1 chr12 13196723 13219941 + FAM47E-STBD1 chr4 76251721 76311129 + KLF4 chr9 107484852 107490482 - LENG8 chr19 54448887 54462037 + LYSMD4 chr15 99715697 99733561 - MLPH chr2 237485428 237555322 + MTMR9 chr8 11284816 11328146 + NDST1 chr5 150485818 150558211 + OSBPL11 chr3 125528858 125595497 - PBXIP1 chr1 154944076 154956123 - PFAS chr17 8247618 8270491 + PGRMC1 chrX 119236245 119244466 + RCC1 chr1 28505943 28539300 + RTKN chr2 74425835 74442422 - STARD13 chr13 33103137 33350630 - STBD1 chr4 76306026 76311599 + SYVN1 chr11 65121780 65134533 - TBC1D5 chr3 17157162 18444817 - TMEM123 chr11 102396332 102470384 - TOMM70 chr3 100363431 100401089 - TRIM3 chr11 6448613 6474459 - USP22 chr17 20999596 21043760 - VPS45 chr1 150067279 150145329 + ZNF512B chr20 63956704 63969930 - miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0000284 chr11 33307958 33309057 + hsa_circ_0000943 chr19 47421744 47440665 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007780.1 chr17 68413623 68524949 + AC073896.4 chr12 56162359 56190284 - AL049840.4 chr14 103694516 103695050 - AL603839.3 chr1 40493157 40508661 - H19 chr11 1995176 2001470 - HCG18 chr6 30286690 30327382 - KCNQ1OT1 chr11 2608328 2699994 - LINC01089 chr12 121795267 121803906 - NEAT1 chr11 65422774 65445540 + NUTM2A-AS1 chr10 87201647 87342612 - NUTM2B-AS1 chr10 79661394 79826594 - XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.