exRNAdisease

Entry Detail

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General Information

Database ID: exR0275380 RNA Name: hsa-miR-185-5p RNA Type: miRNA Chromosome: chr22 Starnd: + Coordinate: Start Site(bp): 20033153 End Site(bp): 20033174 External Links: hsa-miR-185-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand TFAP2A chr6 10393186 10419659 - SSH2 chr17 29625938 29930276 - ZBTB4 chr17 7459366 7484263 - CTSA chr20 45890144 45898820 + TSPAN14 chr10 80454166 80533124 + ACVR1B chr12 51951699 51997078 + GRB2 chr17 75318076 75405709 - RAB5A chr3 19947097 19985175 + RAB40C chr16 589357 629272 + VPS37B chr12 122865330 122896127 - SLC29A1 chr6 44219553 44234142 + NDRG1 chr8 133237171 133302022 - HDLBP chr2 241227264 241317061 - RSU1 chr10 16590611 16817463 - HADHA chr2 26190635 26244672 - VPS4A chr16 69311350 69326939 + IGF2BP1 chr17 48997385 49056145 + NF1 chr17 31094927 31382116 + SMAD3 chr15 67063763 67195169 + ORAI1 chr12 121626550 121642677 + ADGRG1 chr16 57610652 57665580 + TNRC6B chr22 40044817 40335808 + ZMIZ1 chr10 79068966 79316528 + GOLGA1 chr9 124878275 124948492 - ZBTB38 chr3 141324213 141449792 + SLC29A2 chr11 66362521 66372214 - GATAD2B chr1 153789030 153923360 - GBA2 chr9 35736866 35749228 - OTUD4 chr4 145110838 145180589 - FAM234A chr16 234521 272183 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001658 chr6 157357968 157406039 + hsa_circ_0000711 chr16 68155889 68160513 + hsa_circ_0001168 chr20 47691321 47707559 + hsa_circ_0001146 chr20 34241449 34246936 - hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC007952.4 chr17 19112000 19112636 - AC008040.1 chr3 169939353 169966734 - AC021092.1 chr19 44103007 44113183 - LINC01278 chrX 63222993 63561095 - MALAT1 chr11 65497688 65506516 + MIR137HG chr1 97933474 98049863 - MIR663AHG chr20 26167817 26251546 - NEAT1 chr11 65422774 65445540 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.