exRNAdisease

Entry Detail

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General Information

Database ID: exR0275406 RNA Name: hsa-miR-196a-5p RNA Type: miRNA Chromosome: chr17 Starnd: - Coordinate: Start Site(bp): 48632532 End Site(bp): 48632553 External Links: hsa-miR-196a-5p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ACP1 chr2 264140 278283 + ARHGAP28 chr18 6729718 6915716 + ARL5A chr2 151788984 151828492 - C15orf41 chr15 36579626 36810248 + C19orf53 chr19 13774456 13778773 + CBFA2T3 chr16 88874858 88977207 - COL6A2 chr21 46098112 46132848 + CS chr12 56271699 56300391 - FAM222B chr17 28755978 28855232 - FNBP4 chr11 47716494 47767443 - HOXA7 chr7 27153716 27157936 - IGDCC3 chr15 65327127 65378002 - IGF2BP1 chr17 48997385 49056145 + LDOC1 chrX 141111605 141177129 - PDE6D chr2 231732433 231786272 - PFKFB3 chr10 6144934 6254644 + TMEM161B chr5 88189633 88269476 - XPO4 chr13 20777329 20903048 - ZMYND11 chr10 134465 254637 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0000095 chr1 95609446 95616975 + hsa_circ_0001522 chr5 122881110 122893258 + hsa_circ_0000799 chr17 65941524 65972074 + lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005034.3 chr2 75697583 75697996 + ARHGAP27P1-BPTFP1-KPNA2P3 chr17 64749663 64781707 - FGD5-AS1 chr3 14920347 14948424 - GAS5 chr1 173858559 173868882 - H19 chr11 1995176 2001470 - KCNQ1OT1 chr11 2608328 2699994 - NEAT1 chr11 65422774 65445540 + SNHG16 chr17 76557764 76565348 + SNHG3 chr1 28505980 28510892 + TUG1 chr22 30969245 30979395 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.