exRNAdisease

Entry Detail

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General Information

Database ID: exR0275414 RNA Name: hsa-miR-19a-3p RNA Type: miRNA Chromosome: chr13 Starnd: + Coordinate: Start Site(bp): 91350939 End Site(bp): 91350961 External Links: hsa-miR-19a-3p

Disease Information

Disease Name: Advanced Adenoma Disease Category: Cancers MeSH ID: D000236 Type: Neoplasms/Neoplasms, Glandular and Epithelial Alias: Adenoma//Adenomas//Adenoma, Follicular//Adenomas, Follicular//Follicular Adenoma//Follicular Adenomas//Adenoma, Trabecular//Adenomas, Trabecular//Trabecular Adenoma//Trabecular Adenomas//Adenoma, Monomorphic//Adenomas, Monomorphic//Monomorphic Adenoma//Monomorphic Adenomas//Adenoma, Papillary//Adenomas, Papillary//Papillary Adenoma//Papillary Adenomas//Adenoma, Basal Cell//Adenomas, Basal Cell//Basal Cell Adenoma//Basal Cell Adenomas//Adenoma, Microcystic//Adenomas, Microcystic//Microcystic Adenoma//Microcystic Adenomas

Expression Detail

GEO ID: GSE25609 Description: Plasma microRNA profiling by microarray elucidates several candidate biomarkers for colorectal cancer screening Experimental Design: Cancer vs Control Case Disease Type: Advanced Adenoma Case Disease SubType: NA Case Sample: Advanced Adenoma Post surgery Control Sample: Control Number of Case: 20 Number of Control: 20 Number of Samples: 40

Regulatory Relationship

mRNA targets: Gene Symbol Chromosome Start Site(bp) End Site(bp) Strand ATP6V1B2 chr8 20197381 20226819 + BCL7A chr12 122019422 122062044 + BRWD1 chr21 39184176 39321559 - BTBD7 chr14 93237550 93333092 - CAMTA1 chr1 6785454 7769706 + CASP2 chr7 143288215 143307696 + CCDC47 chr17 63745255 63776351 - DNAJC16 chr1 15526813 15592379 + HIP1 chr7 75533298 75738962 - HOMER1 chr5 79372636 79514134 - MEF2D chr1 156463727 156500779 - MYLIP chr6 16129086 16148248 + RCOR1 chr14 102592649 102730561 + RFX1 chr19 13961530 14007039 - RPS23 chr5 82273320 82278396 - TMEM181 chr6 158536436 158635428 + ATF7IP chr12 14365632 14502935 + CAMSAP1 chr9 135808487 135907546 - CDS1 chr4 84583127 84651334 + CHIC1 chrX 73563200 73687102 + DTL chr1 212035553 212107400 + MARCKS chr6 113857345 113863475 + SCYL2 chr12 100267140 100341715 + SPAG7 chr17 4959226 4967817 - SPOPL chr2 138501770 138573547 + STK33 chr11 8391868 8594289 - TNFRSF12A chr16 3018445 3022383 + miRNA targets: NA circRNA targets: circRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand hsa_circ_0001454 chr4 154524454 154533552 + hsa_circ_0001186 chr21 35475133 35475818 + hsa_circ_0000384 chr12 27867712 27877119 + hsa_circ_0001605 chr6 42903447 42905047 + hsa_circ_0000155 chr1 168007608 168014465 + hsa_circ_0001495 chr5 68470703 68471364 + hsa_circ_0000943 chr19 47421744 47440665 + hsa_circ_0001164 chr20 45891031 45923523 - lncRNA targets: lncRNA Symbol Chromosome Start Site(bp) End Site(bp) Strand AC005394.2 chr19 28435388 28727680 - AC010997.3 chr10 75279726 75401246 - AC011498.2 chr19 4447304 4448217 + AC011503.2 chr19 23927788 23929287 + AC021078.1 chr5 149494314 149504670 - AC135050.6 chr16 31122235 31124064 + AL049840.4 chr14 103694516 103695050 - AL158206.1 chr9 19453209 19455173 + AL158825.2 chr9 75009828 75016036 - H19 chr11 1995176 2001470 - HAGLR chr2 176164051 176188958 - LAMTOR5-AS1 chr1 110347116 110443817 + LINC00667 chr18 5237826 5290608 + MCM3AP-AS1 chr21 46229196 46259390 + NEAT1 chr11 65422774 65445540 + SNHG20 chr17 77086716 77099902 + XIST chrX 73820649 73852723 - Display:

Experiment Detail

GEO ID: GSE25609 Sample Source: Blood Source Fraction: Plasma Platform: GPL8179 Method: Microarray Num of detected RNA Type: 1 Num of detected RNAs of this Type: 826 Sample treatment protocol: Briefly, samples were centrifuged at 1,600×g for 10 min at 4 ºC to spin down blood cells, and plasma was transferred into new tubes, followed by further centrifugation at 16,000×g for 10 minutes at 4ºC to completely remove cellular components. RNA Extract protocol: NA RNA library preparation protocol: Biotinylated cDNA were prepared with the Illumina® TotalPrep™ RNA Amplification Kit (Ambion).

Reference

PMID: 23267864 Title: Circulating microRNAs as biomarkers of colorectal cancer: results from a genome-wide profiling and validation study Author: Gir¨¢ldez MD, Lozano JJ, Ram¨ªrez G, Hijona E, Bujanda L, Castells A, Gironella M Journal: Clin Gastroenterol Hepatol. 2013 Jun;11(6):681-8.e3. Description: We investigated whether plasma levels of miRNA can differentiate patients with CRC from healthy individuals. We also investigated whether plasma samples from patients with premalignant neoplastic lesions, such as advanced adenomas (AAs), also had a different expression pattern of miRNAs.